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These results provide strong evidence that CRP is not only a marker MM, but is an important regulator of the survival of myeloma cells. CRP protects myeloma cells from apoptosis induced by chemotherapeutic drugs and stimulates myeloma cells to innermost IL 6, which in turn provides additional protection from myeloma and stimulates apoptosis of liver cells to secrete more CRP. And CRP could be a therapeutic target for breaking the vicious circle of myeloma to improve the therapeutic effect of treatments available, 'says Dr.
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